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No. 56 November/December 2007


Low-dose exposure and immunogenicity of transgenic maize expressing the Escherichia coli heat-labile toxin B subunit.
Environmental Health Perspectives 115(3):354-360.
November 8, 2007
Synopsis by Rick Stahlhut, Ph.D. and Wendy Hessler
Beyer AJ, K Wang, AN Umble, JD Wolt and JE Cunnick. 2007.


Minute quantities of a bacterial protein inserted in corn provoke immune reactions in mice. The protein is added to increase the effectiveness of plant-based transgenic vaccines. The results indicate that special care will be needed with transgenic corn to reduce exposure to workers and the public if this protein is used commercially in corn or other food crops, to avoid unwanted immune responses in people and decreased effectiveness of oral vaccines that use the protein.
Eating extremely small amounts of LT-B several times over less than a month caused exposed mice to develop immune reactions to the protein.

Web Link: http://www.environmentalhealthnews.org/newscience/2007/2007-
1109beyeretal.html#2007morovecetal

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